Atxn7
Function
Involved in neurodegeneration. Acts as a component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity).
Post-translational modifications
Proteolytically cleaved by caspase-7 (CASP7).
Sumoylation has no effect on subcellular location or interaction with components of the STAGA complex.
Sequence Similarities
Belongs to the ataxin-7 family.
Tissue Specificity
Widely expressed in adult tissues, with the highest expression in heart, brain, liver and kidney.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
- Nucleus matrix
- Cytoplasm
- Cytoskeleton
- In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus. It is able to shuttle between the nucleus and cytoplasm (By similarity).
Alternative names
Sca7, Atxn7, Ataxin-7, Spinocerebellar ataxia type 7 protein homolog