Avil
Developmental stage
Expressed almost exclusively in peripheral sensory neurons (craniofacial and dorsal root ganglia (DRG) sensory neurons), but also in trigeminal ganglia (TG) Me5 proprioceptive neurons and Mo5 motoneurons.
Function
Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis (PubMed:15247299, PubMed:18160648). In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity).
Sequence Similarities
Belongs to the villin/gelsolin family.
Tissue Specificity
Most highly expressed in the endometrium of the uterus, the intestinal villi and the testes. Weaker expression also detected in the brain, dorsal root ganglions and on the surface of the tongue.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell projection
- Lamellipodium
- Cell junction
- Focal adhesion
- Cell projection
- Neuron projection
- Cell projection
- Axon
- In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions.
Alternative names
Advil, Advillin, Actin-binding protein DOC6, p92