AVP
Function
Neurophysin 2
Specifically binds vasopressin.
Arg-vasopressin
Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156).
Involvement in disease
Diabetes insipidus, neurohypophyseal
NDI
A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the vasopressin/oxytocin family.
Cellular localization
- Secreted
Alternative names
ARVP, VP, AVP, Vasopressin-neurophysin 2-copeptin, AVP-NPII