The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Colorectal cancer
CRC
A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
None
The gene represented in this entry is involved in disease pathogenesis.
Oligodontia-colorectal cancer syndrome
ODCRCS
Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
None
The disease is caused by variants affecting the gene represented in this entry.
Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
Expressed in brain and lymphoblast.
Axin-2, Axin-like protein, Axis inhibition protein 2, Conductin, Axil, AXIN2
Proteins
Oncology
93558Da
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ab204097