B3GALT2
Function
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.
Pathway
Protein modification; protein glycosylation.
Sequence Similarities
Belongs to the glycosyltransferase 31 family.
Tissue Specificity
Detected in heart and brain.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
Alternative names
Beta3Gal-T2, Beta3GalT2, UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2, B3GALT2