Bak
Domain
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Function
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2.
Sequence Similarities
Belongs to the Bcl-2 family.
Tissue Specificity
Widely expressed.
Cellular localization
- Mitochondrion outer membrane
- Single-pass membrane protein
Alternative names
Bak, Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK