BAMBI
Developmental stage
Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.
Function
Negatively regulates TGF-beta signaling.
Sequence Similarities
Belongs to the BAMBI family.
Tissue Specificity
High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
NMA, BAMBI, BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA