BATF3

Function

AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.

Sequence similarities

Belongs to the bZIP family.

Cellular localization

• Nucleus

Alternative names

• Basic leucine zipper transcriptional factor ATF-like 3
• B-ATF-3
• 21 kDa small nuclear factor isolated from T-cells
• Jun dimerization protein p21SNFT
• BATF3
• SNFT

Database links

• entrezGene:55509
• omim:612470
• swissprot:Q9NR55

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

14468Da