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BATF3

Function

AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.

Sequence similarities

Belongs to the bZIP family.

Cellular localization

  • Nucleus

Alternative names

  • Basic leucine zipper transcriptional factor ATF-like 3
  • B-ATF-3
  • 21 kDa small nuclear factor isolated from T-cells
  • Jun dimerization protein p21SNFT
  • BATF3
  • SNFT

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

14468Da