BBC3
Domain
The BH3 motif is intrinsically disordered in the absence of a binding partner but folds upon binding (PubMed:23340338). Folds when bound to BCL2L1 (PubMed:23340338). Also folds when bound to MCL1 (By similarity).
Function
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity).
Sequence Similarities
Belongs to the Bcl-2 family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Mitochondrion
- Localized to the mitochondria in order to induce cytochrome c release.
Alternative names
PUMA, BBC3, JFY-1, p53 up-regulated modulator of apoptosis