BCAN
Developmental stage
Expressed between 6 and 19 weeks post-conception (WPC) in the outer neuroblastic zone, inner neuroblastic zone, and inner plexiform layer of the retina (at protein level) (PubMed:29777959). Expressed at the surface ectoderm at 6 WPC and the neural retinal at 6 to 8 WPC (at protein level) (PubMed:29777959). Expressed in the interphotoreceptor matrix and abundantly in developing photoreceptors between 12 and 19 WPC (at protein level) (PubMed:29777959). Isoform 1: Highly expressed from birth through 8 years of age and is down-regulated by 20 years of age to low levels that are maintained in the normal adult cortex (PubMed:11054543). Isoform 2: Expressed at uniformly low levels throughout development (PubMed:11054543).
Function
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Post-translational modifications
O-glycosylated; contains chondroitin sulfate (PubMed:25326458). O-glycosylated with a core 1 or possibly core 8 glycan (PubMed:19838169).
Sequence Similarities
Belongs to the aggrecan/versican proteoglycan family.
Tissue Specificity
Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level) (PubMed:29777959). Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717).
Cellular localization
- Secreted
- Isoform 1
- Secreted
- Extracellular space
- Extracellular matrix
- Isoform 2
- Membrane
- Lipid-anchor
- GPI-anchor
Alternative names
BEHAB, CSPG7, UNQ2525/PRO6018, BCAN, Brevican core protein, Brain-enriched hyaluronan-binding protein, Chondroitin sulfate proteoglycan 7