Bcat1
Developmental stage
Highly expressed at day 9 of embryogenesis. Expression decreases to moderate levels through day 13. In the developing embryo, expressed in the brain, somites and mesenophric tubules.
Function
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Sequence Similarities
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Tissue Specificity
Expressed in brain and kidney. Overexpressed in MYC-induced brain tumors, lymphomas, as well as in a teratocarcinoma cell line.
Cellular localization
- Cytoplasm
Alternative names
Eca39, Bcat1, BCAT(c)