Bcl2l11 phospho S65
Domain
The BH3 motif is required for the interaction with Bcl-2 proteins and cytotoxicity.
Function
Induces apoptosis and anoikis.
Post-translational modifications
Phosphorylation at Ser-65 by MAPK1/MAPK3 leads interaction with TRIM2 and ubiquitination, followed by proteasomal degradation. Deubiquitination catalyzed by USP27X stabilizes the protein.
Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation (PubMed:21478148). Conversely, deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
Sequence Similarities
Belongs to the Bcl-2 family.
Tissue Specificity
Widely expressed.
Cellular localization
- Membrane
- Peripheral membrane protein
- Mitochondrion
- Associated with intracytoplasmic membranes.
Alternative names
Bim, Bod, Bcl2l11, Bcl-2-like protein 11, Bcl2-L-11, Bcl-2-related ovarian death protein, Bcl2-interacting mediator of cell death