BCL3

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit (By similarity). In the nucleus, acts as a transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.

Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation.

Activated by phosphorylation.

• Nucleus
• Cytoplasm
• Cytoplasm
• Perinuclear region
• Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.

B-cell lymphoma 3 protein homolog, BCL-3

• swissprot:Q9Z2F6

Proteins

Epigenetics