BCL3
Function
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
Involvement in disease
A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
Post-translational modifications
Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).
Activated by phosphorylation.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoplasm
- Perinuclear region
- Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
Alternative names
BCL4, D19S37, BCL3, B-cell lymphoma 3 protein, BCL-3, Proto-oncogene BCL3