BDNF
Function
Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
Post-translational modifications
Neurotrophic factor BDNF precursor form
N-glycosylated and glycosulfated, contrary to mature BDNF.
Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
Sequence Similarities
Belongs to the NGF-beta family.
Cellular localization
- Secreted
- Neurotrophic factor BDNF precursor form
- Secreted
- A proportion of BDNF is secreted as immature precursor (proBDNF).
Alternative names
Neurotrophic factor BDNF precursor form, proBDNF, Brain-derived neurotrophic factor, BDNF