BEST4

Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by Calcium (Ca2+) (PubMed:12907679, PubMed:18400985). Mediates the movement of hydrogencarbonate and chloride (PubMed:12907679, PubMed:18400985).

Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.

Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta.

• Cell membrane
• Multi-pass membrane protein

VMD2L2, BEST4, Bestrophin-4, Vitelliform macular dystrophy 2-like protein 2

• entrezGene:266675
• omim:607336
• swissprot:Q8NFU0

Proteins

53497Da