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Beta-defensin 1

Function

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.

Sequence Similarities

Belongs to the beta-defensin family.

Tissue Specificity

Detected in kidney.

Cellular localization

Alternative names

Beta-defensin 1, BD-1, mBD-1, Defb1

swissprot:P56386 entrezGene:13214