BEX1
Domain
The histidine cluster (His cluster) and Cys-122 mediate zinc-binding.
Function
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Post-translational modifications
Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome.
Ubiquitinated. Degraded by the proteasome.
Sequence Similarities
Belongs to the BEX family.
Tissue Specificity
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.
Cellular localization
- Nucleus
- Cytoplasm
- Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.
Alternative names
Protein BEX1, Brain-expressed X-linked protein 1, BEX1