The histidine cluster (His cluster) and Cys-122 mediate zinc-binding.
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome.
Ubiquitinated. Degraded by the proteasome.
Belongs to the BEX family.
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.
Protein BEX1, Brain-expressed X-linked protein 1, BEX1
Proteins
14860Da
We found 1 product in 1 category