Bid
Domain
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.
Function
Induces caspases and apoptosis. Counters the protective effect of BCL2.
BH3-interacting domain death agonist p15
Induces caspase activation and apoptosis (By similarity). Allows the release of cytochrome c (PubMed:9873064).
Post-translational modifications
BH3-interacting domain death agonist
TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (PubMed:9873064). Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis (By similarity).
BH3-interacting domain death agonist p15
Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
Cellular localization
- Cytoplasm
- Mitochondrion membrane
- Mitochondrion outer membrane
- When uncleaved, it is predominantly cytoplasmic.
- BH3-interacting domain death agonist p15
- Mitochondrion membrane
- Translocates to mitochondria as an integral membrane protein.
- BH3-interacting domain death agonist p13
- Mitochondrion membrane
- Associated with the mitochondrial membrane.
Alternative names
BH3-interacting domain death agonist, p22 BID, BID, Bid