BIN2
Domain
The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
Function
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
Tissue Specificity
Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
Cellular localization
- Cytoplasm
- Cell projection
- Podosome membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
- Cell cortex
- Cell projection
- Phagocytic cup
- Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.
Alternative names
BRAP1, BIN2, Bridging integrator 2, Breast cancer-associated protein 1