BLCAP
Function
Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms (PubMed:16675915, PubMed:17031575, PubMed:21844121, PubMed:26986503). Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis (PubMed:17031575, PubMed:21844121, PubMed:26986503).
Sequence Similarities
Belongs to the BLCAP family.
Tissue Specificity
Cervical tissues (at protein level) (PubMed:22969892). Urothelium (at protein level) (PubMed:19783793, PubMed:29190807). Endothelial cells of urinary bladder vessels (at protein level) (PubMed:19783793). Urinary bladder stromal cells (at protein level) (PubMed:19783793). Cervical tissues (PubMed:16675915). Kidney (PubMed:11072240). Ubiquitous (PubMed:19908260).
Cellular localization
- Cytoplasm
- Nucleus
- Membrane
- Multi-pass membrane protein
Alternative names
BC10, BLCAP, Apoptosis inducing factor BLCAP, Bladder cancer 10 kDa protein, Bladder cancer-associated protein, Bc10