BLMH
Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Sequence Similarities
Belongs to the peptidase C1 family.
Cellular localization
- Cytoplasm
- Cytoplasmic granule
- Co-localizes with NUDT12 in the cytoplasmic granules.
Alternative names
Bleomycin hydrolase, BH, BLM hydrolase, BMH, BLMH