BLOC1S2
Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421).
Sequence Similarities
Belongs to the BLOC1S2 family.
Tissue Specificity
Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level).
Cellular localization
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Lysosome membrane
- Localizes to the centrosomes in a microtubule-dependent manner.
Alternative names
BLOS2, CEAP, BLOC1S2, Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2, Centrosome-associated protein