BLZF1

The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.

Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.

ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.

Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation.

Detected in adrenal gland (PubMed:9129147).

• Golgi apparatus membrane
• Isoform 1
• Nucleus
• Detected in the nucleus upon heterologous expression. Not detected in the cytoplasm.
• Isoform 2
• Cytoplasm
• Not detected in the nucleus.

JEM1, BLZF1, Golgin-45, Basic leucine zipper nuclear factor 1, JEM-1, p45 basic leucine-zipper nuclear factor

• entrezGene:8548
• omim:608692
• swissprot:Q9H2G9

Proteins

44910Da