BLZF1
Domain
The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
Function
Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
Post-translational modifications
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation.
Tissue Specificity
Detected in adrenal gland (PubMed:9129147).
Cellular localization
- Golgi apparatus membrane
- Isoform 1
- Nucleus
- Detected in the nucleus upon heterologous expression. Not detected in the cytoplasm.
- Isoform 2
- Cytoplasm
- Not detected in the nucleus.
Alternative names
JEM1, BLZF1, Golgin-45, Basic leucine zipper nuclear factor 1, JEM-1, p45 basic leucine-zipper nuclear factor