Bmi1 phospho T275
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).
Post-translational modifications
May be polyubiquitinated; which does not lead to proteasomal degradation (By similarity). Monoubiquitinated.
Tissue Specificity
Detected in most organs with high expression levels in thymus, heart, brain and testis.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
Bmi-1, Pcgf4, Bmi1, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4
Database links
Other research areas
- Oncology