BMP15
Function
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Involvement in disease
Ovarian dysgenesis 2
ODG2
A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
None
The disease is caused by variants affecting the gene represented in this entry.
Premature ovarian failure 4
POF4
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the TGF-beta family.
Cellular localization
- Secreted
Alternative names
GDF9B, BMP15, Bone morphogenetic protein 15, BMP-15, Growth/differentiation factor 9B, GDF-9B