BMP2
GeneName
BMP2
Summary
BMP2, also known as BMP-2 or bone morphogenetic protein 2, is a 45kDa secreted protein that plays a crucial role in various biological processes, particularly in bone development and morphogenesis. It is expressed in multiple tissues and localised to the extracellular region, where it interacts with BMP receptors and co-receptors to mediate signalling pathways. BMP2 is involved in the differentiation of various cell types, including osteoblasts, chondrocytes, and astrocytes, and is essential for processes such as organ morphogenesis, cardiac development, and the regulation of cell fate. Its activity is linked to the BMP signalling pathway, which influences cellular responses and interactions during embryonic development and tissue homeostasis.
Importance
BMP2 is relevant to: - Bone regeneration and repair, making it a target for therapeutic applications in orthopaedics and dentistry - Developmental biology, particularly in understanding organogenesis and tissue differentiation - Cardiovascular research, due to its role in heart development and cardiac cell differentiation - Cancer research, as it may influence tumour microenvironments and metastatic processes through its effects on cell signalling and differentiation
Top Products
For researchers investigating BMP2, we recommend two excellent primary antibodies that cater to different needs. The first is the well-cited polyclonal antibody, Anti-BMP2 antibody (ab14933), which has garnered 197 citations, underscoring its reliability in Western blotting (WB). This antibody is a trusted choice for those focusing on BMP2 detection in their experiments. Additionally, we offer the recombinant antibody, Anti-BMP2 antibody [EPR20807] (ab214821), which is suitable for a broader range of applications, including WB, immunocytochemistry (ICC), and flow cytometry (FC). With 87 citations, this recombinant product provides the batch-to-batch consistency that many researchers seek. Together, these antibodies provide versatile options for studying BMP2 effectively. The Anti-BMP2 antibody [EPR20807] ELISA Kit (ab214821), supported by 87 citations, is an excellent option for researchers looking to accurately measure BMP2 levels in their samples.
Abcam Product Citation Summary
The data indicates that BMP2 is a significant target in various studies related to osteogenic differentiation, angiogenesis, and bone metabolism. The use of Abcam antibodies in both human and rodent models highlights the relevance of BMP2 in different biological contexts, including periodontal ligament cells, endothelial cells, and hepatocellular carcinoma tissues. The applications of Western blotting and immunohistochemistry suggest a focus on protein expression and localisation in these studies.
Abcam Product Citation Table
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:24362451, PubMed:31019025). Induces cartilage and bone formation (PubMed:3201241). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:16771708, PubMed:20851880). Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity).
Involvement in disease
Brachydactyly A2
BDA2
A form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type A2 shortening of the middle phalanges is confined to the index finger and the second toe, all other digits being more or less normal. Because of a rhomboid or triangular shape of the affected middle phalanx, the end of the second finger usually deviates radially.
None
The gene represented in this entry is involved in disease pathogenesis. Duplications of a cis-regulatory element located approximately 110 kb downstream of BMP2 have been found in BDA2 families. They likely cause altered BMP2 expression with pathological consequences.
Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1
SSFSC1
An autosomal dominant disorder characterized by short stature, facial dysmorphism, skeletal anomalies, and variable cardiac defects. Distinctive facial features include midface retrusion, short upturned nose, long philtrum, high-arched or cleft palate, and variable degrees of micrognathia and dental crowding. Skeletal anomalies include patterning defects of the axial skeleton, characterized by 11 pairs of ribs and brachydactyly of the fifth ray. Congenital heart defects are variably observed and appear to involve primarily the cardiac outflow tract.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the TGF-beta family.
Tissue Specificity
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Cellular localization
- Secreted
Alternative names
BMP2A, BMP2, Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A