Bone sialoprotein 2
Domain
The Arg-Gly-Asp (RGD) sequence serves as an integrin-binding motif and is required for integrin-mediated cell attachment.
Function
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3).
Cellular localization
- Secreted
Alternative names
Integrin-binding sialoprotein, Bone sialoprotein 2, Bone sialoprotein II, Cell-binding sialoprotein, BSP II, Ibsp