Brain protein I3
Function
Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).
Sequence Similarities
Belongs to the BRI3 family.
Cellular localization
- Lysosome membrane
- Multi-pass membrane protein
- Isoform 1
- Cytoplasm
- Perinuclear region
- Co-localizes with MGAT1 and IFITM3 at the perinuclear region.
- Isoform 2
- Cytoplasm
- Nucleus
- Diffuse localization in the cytoplasm and nucleus.
Alternative names
Membrane protein BRI3, Brain protein I3, pRGR2, BRI3