BRAP
Function
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Pathway
Protein modification; protein ubiquitination.
Tissue Specificity
Expressed in breast epithelial cell lines.
Cellular localization
- Cytoplasm
Alternative names
RNF52, BRAP, BRCA1-associated protein, BRAP2, Impedes mitogenic signal propagation, RING finger protein 52, RING-type E3 ubiquitin transferase BRAP2, Renal carcinoma antigen NY-REN-63, IMP