BRAP

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Protein modification; protein ubiquitination.

Expressed in breast epithelial cell lines.

• Cytoplasm

RNF52, BRAP, BRCA1-associated protein, BRAP2, Impedes mitogenic signal propagation, RING finger protein 52, RING-type E3 ubiquitin transferase BRAP2, Renal carcinoma antigen NY-REN-63, IMP

• entrezGene:8315
• omim:604986
• swissprot:Q7Z569

Proteins

Oncology

67305Da