BRD1
Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189).
Tissue Specificity
Highly expressed in testis.
Cellular localization
- Nucleus
- Chromosome
- Localizes to transcription start sites.
Alternative names
BRL, BRPF2, BRD1, Bromodomain-containing protein 1, BR140-like protein, Bromodomain and PHD finger-containing protein 2