BRINP3
Function
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
Sequence Similarities
Belongs to the BRINP family.
Tissue Specificity
Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
Cellular localization
- Secreted
- Mitochondrion
Alternative names
DBCCR1L, DBCCR1L1, FAM5C, BRINP3, BMP/retinoic acid-inducible neural-specific protein 3, DBCCR1-like protein 1