BSG

In developing eye expressed at embryonic days 12 dpc, 15 dpc and 18 dpc, and at postnatal days P1, P7, P14, and P21. Expression progressed from a more generalized distribution throughout the undifferentiated neural retina to specific staining of retina-pigmented epithilia, the MCs, photoreceptor cells and the ciliary apparatus. Expression is highest at P21. Isoform 1 and isoform 2 are expressed at equivalent levels at P7, isoform 1 is more abundant at P14, P21 and P28. In uterus during the peri-implantation period strongly expressed in luminal and glandular epithelium on day 1 of pregnancy and gradually decreased to a basal level from day 2-4 of pregnancy. Expression in the sub-luminal stroma was first detected on day 3 of pregnancy and increased on day 4 of pregnancy. On day 5 of pregnancy, the expression of basigin protein and mRNA was only detected in the implanting embryos, and the luminal epithelium and sub-luminal stroma surrounding the embryos. In ovary during sexual maturation expressed in the granulosa cells of preantral follicles at days 20 and 25 after birth. Expressed during corpus luteum formation.

Isoform 1

Essential for normal retinal maturation and development (PubMed:10967074, PubMed:11273674, PubMed:11853760). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).

Isoform 2

Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane (PubMed:12601063). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (PubMed:11882021, PubMed:23727514).

Isoform 1

N-glycosylated.

Isoform 2

N-glycosylated (PubMed:12558975, PubMed:23727514). During spermatogenesis, probably deglycosylated during epididymal transit (PubMed:11882021).

Isoform 1

Retina-specific (PubMed:11273674, PubMed:11853760, PubMed:12939332, PubMed:25957687). Expressed in both rods and cones (at protein level) (PubMed:25957687).

Isoform 2

Testis and caput, corpus and cauda epididymides (at protein level) (PubMed:11882021, PubMed:21792931, PubMed:23727514). Expressed in the brain, lung, liver, kidney, heart, spleen, uterus, retina and skeletal muscle (PubMed:12601063, PubMed:12939332, PubMed:2361961).

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Photoreceptor inner segment
• Cell projection
• Cilium
• Photoreceptor outer segment
• Isoform 2
• Cell membrane
• Single-pass type I membrane protein
• Endoplasmic reticulum membrane
• Single-pass type I membrane protein
• Basolateral cell membrane
• Single-pass type I membrane protein

CD147, Basigin, Basic immunoglobulin superfamily, HT7 antigen, Membrane glycoprotein gp42, Bsg

• entrezGene:12215
• swissprot:P18572

Proteins

Immunology & Infectious Disease

42445Da