BTB/POZ domain-containing protein KCTD21
Function
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
Pathway
Protein modification; protein ubiquitination.
Tissue Specificity
Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
Alternative names
BTB/POZ domain-containing protein KCTD21, KCASH2 protein, Potassium channel tetramerization domain-containing protein 21, KCTD21