BTBD8
Developmental stage
Expressed mainly in fetal tissues.
Function
Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
Tissue Specificity
Highly expressed in fetal brain. Weakly expressed in adult brain and prostate.
Cellular localization
- Cell projection
- Axon
- Presynapse
- Cytoplasmic vesicle
- Clathrin-coated vesicle
- Nucleus
- In primary cultures, mainly present at axonal and presynaptic terminal levels of mature neurons. In immature neurons, localizes to the cell body and growing processes, including axons (By similarity). Localized to nucleus in fetal cells (PubMed:14654994).
Alternative names
KIAA1107, BTBD8, BTB/POZ domain-containing protein 8, AP2-interacting clathrin-endocytosis, APache