BTF3
Function
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.
Sequence Similarities
Belongs to the NAC-beta family.
Cellular localization
- Cytoplasm
- Nucleus
- The heterodimer with NACA is cytoplasmic.
Alternative names
NACB, OK/SW-cl.8, BTF3, Transcription factor BTF3, Nascent polypeptide-associated complex subunit beta, RNA polymerase B transcription factor 3, NAC-beta