BTG4
Function
Adapter protein that bridges CNOT7, a catalytic subunit of the CCR4-NOT complex, to EIF4E (By similarity). Facilitates maternal mRNAs decay during the maturation of oocytes and in the fertilized egg, and is required for the maternal-zygotic transition (MZT), zygotic cleavage and initiation of embryonic development (PubMed:32502391).
Involvement in disease
Oocyte/zygote/embryo maturation arrest 8
OZEMA8
An autosomal recessive infertility disorder due to failure of the fertilized ovum to undergo zygotic cleavage.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the BTG family.
Tissue Specificity
Expressed in oocytes after germinal vesicle breakdown (PubMed:32502391). Expressed in testis and in olfactory epithelium.
Alternative names
PC3B, BTG4, Protein BTG4, BTG family member 4, Protein PC3b