Btla

Function

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).

Post-translational modifications

Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.

N-glycosylated.

Tissue Specificity

Expressed in splenic T- and B-cells as well as lymph node tissues but very weakly in somatic tissues. Also expressed in macrophages, NK cells and dendritic cells. A polymorphic tissue distribution between several strains is seen.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, Btla

Database links

swissprot:Q7TSA3 entrezGene:208154

Other research areas

• Immunology & Infectious Disease