BTN3A1
Function
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Tissue Specificity
Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD277, BTF5, BTN3A1, Butyrophilin subfamily 3 member A1