BTNL8
Function
May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.
Sequence Similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Tissue Specificity
Expressed in neutrophils. Isoforms 1 and 5 are expressed at high levels in the colon, lung,testis, lymph nodes and thyroid tissue. Isoform 5, but not isoform 1, is detected in spleen.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
UNQ702/PRO1347, BTNL8, Butyrophilin-like protein 8