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BZW1

Developmental stage

Expressed in day 3 embryo.

Function

Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015).

Sequence Similarities

Belongs to the BZW family.

Alternative names

5MP2, BZAP45, KIAA0005, BZW1, eIF5-mimic protein 2, Basic leucine zipper and W2 domain-containing protein 1, Protein Orf

swissprot:Q7L1Q6 entrezGene:9689