BZW2
Function
Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931).
Sequence Similarities
Belongs to the BZW family.
Cellular localization
- Cytoplasm
Alternative names
5MP1, HSPC028, MSTP017, BZW2, eIF5-mimic protein 1, Basic leucine zipper and W2 domain-containing protein 2