C1GALT1
Function
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed:11677243). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity).
Pathway
Protein modification; protein glycosylation.
Sequence Similarities
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
Tissue Specificity
Widely expressed. Highly expressed in kidney, heart, placenta and liver.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, B3Gal-T8, Core 1 O-glycan T-synthase, C1GalT1, Core 1 beta3-Gal-T1, C1GALT1