C1QTNF12
Function
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
Post-translational modifications
Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage.
Sequence Similarities
Belongs to the adipolin/erythroferrone family.
Tissue Specificity
Predominantly expressed by adipose tissues.
Cellular localization
- Adipolin fC1QTNF12
- Secreted
- Adipolin gC1QTNF12
- Secreted
- In sera is the predominant form.
Alternative names
C1QDC2, CTRP12, FAM132A, C1QTNF12, Adipolin, Adipose-derived insulin-sensitizing factor, C1q and TNF related protein 12, Complement C1q tumor necrosis factor-related protein 12