C2CD5
Domain
The C2 domain binds to calcium and membrane lipids.
Function
Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Post-translational modifications
Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane.
Cellular localization
- Cytoplasmic vesicle membrane
- Cytoplasm
- Cell cortex
- Cell membrane
- Cell projection
- Ruffle
- Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation.
Alternative names
CDP138, KIAA0528, C2CD5, C2 domain-containing protein 5, C2 domain-containing phosphoprotein of 138 kDa