C4 binding protein/C4BPB

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.

• Secreted

C4b-binding protein beta chain, C4BPB

• entrezGene:725
• omim:120831
• swissprot:P20851

Proteins

Immunology & Infectious Disease

28357Da