C5ar1

Function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.

Post-translational modifications

Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.

Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Cellular localization

• Cell membrane
• Multi-pass membrane protein
• Cytoplasmic vesicle
• Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.

Alternative names

CD88, C5ar, C5r1, C5ar1, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR

Database links

swissprot:P30993 entrezGene:12273 swissprot:Q3TZ86

Other research areas

• Immuno-oncology