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GPCR C5L2

Function

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Frontal cortex, hippocampus, hypothalamus, pons and liver.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • C5a anaphylatoxin chemotactic receptor 2
  • Complement component 5a receptor 2
  • G-protein coupled receptor 77
  • GPR77
  • C5L2
  • C5AR2

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

  • Oncology

Molecular weight

36080Da