C5AR2

Function

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

Frontal cortex, hippocampus, hypothalamus, pons and liver.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

C5L2, GPR77, C5AR2, C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77

Database links

swissprot:Q9P296 omim:609949 entrezGene:27202

Other research areas

• Oncology