C7
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
Involvement in disease
Complement component 7 deficiency
C7D
A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Post-translational modifications
C7 has 28 disulfide bridges.
C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Sequence Similarities
Belongs to the complement C6/C7/C8/C9 family.
Cellular localization
- Secreted
Alternative names
Complement component C7, C7