C8a
Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity).
Sequence Similarities
Belongs to the complement C6/C7/C8/C9 family.
Cellular localization
- Secreted
- Cell membrane
- Multi-pass membrane protein
- Secreted as soluble protein. Inserts into the cell membrane of target cells (By similarity).
Alternative names
Complement component C8 alpha chain, Complement component 8 subunit alpha, C8a